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British Journal of Anaesthesia, 1993, Vol. 70, No. 3 363-364
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

letter

ACCUMLATION OF ACETONE IN BLOOD DURING LONG-TERM ANAESTHESIA WITH CLOSED SYSTEMS

J. M. STRAUB, M.D. and J. HAUSDÖRFER, M.D.

Department of Anaesthesia III, Medizinische Hochschule Hannover P.O. Box, D-3000 Hannover 61, Germany

During closed system anaesthesia with isof/urane, patients with a preoperative increase in blood concentration of acetone (<10 mg litre-1) had a significantly greater concentration of acetone than patients with an initial normal blood concentration of acetone (P 7< 0.01). Flushing the closed system with a high flow of fresh gas had no effect on the blood concentration of acetone. Using a large fresh gas flow, there was no increase in blood acetone concentration. Acetone concentrations of about 50 mg litre-1 cause problems such as nausea and vomiting in the postoperative period. These symptoms occurred more frequently after closed system anaesthesia. (Br. J. Anaesth. 1993; 70: 363–364)


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