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British Journal of Anaesthesia, 1993, Vol. 70, No. 3 322-325
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PLATELET SEROTONIN IS A MEDIATOR POTENTIALLY INVOLVED IN ANAPHYLACTIC REACTION TO NEUROMUSCULAR BLOCKING DRUGS

N. BERMEJO, M.D., J. L. GUÉANT, M.D., D.SC;*, E. MATA, M.D, P. GGUÉRARD, B.SC., D. A. MONERET-VAUTRIN, M.D.; and M. C. LAXENAIRE, M.D

Laboratoire de Biochimie Nutritionnelle, INSERM U 308 and Department of Anacsthesiology, Medical Faculty and University Hospital of Nancy BP 184, 54505, Vandoeuvre-les-Nancy Cedex, France

*Address for correspondence: Laboratory of Biochemistry, Medical Faculty, University of Nancy, BP 184, 54505 Vandoeuvre les Nancy Cedex, France.

A platelet serotonin release test was performed on blood from 10 patients who had suffered from an IgE-dependent allergic reaction to a neuromuscular blocking drug. The results were compared with those of a leukocyte histamine release test. The upper limit of serotonin release induced by neuromuscular blockers was estimated to be 2.3% in non-allergic patients. The test was positive in six patients and was consistent with histamine release in five. Serotonin re/ease induced by neuromuscular blockers comprised 2.9–25% of total platelet serotonin content. We conclude that serotonin is one of the mediators associated with histamine release during anaphylaxis to neuromuscular blockers. Platelet serotonin release tests may be useful for the investigation of anaphylactic responses to neuromuscular blocking drugs. (Br. J. Anaesth. 1993; 70: 322–325)


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