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British Journal of Anaesthesia, 1993, Vol. 70, No. 3 317-321
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

BENZODIAZEPINES AND THEIR SOLVENTS INFLUENCE NEUTROPHIL GRANULOCYTE FUNCTION

M. WEISS, M.D, N. MIROW, MED, A. BIRKHAHN, MED, M. SCHNEIDER, PH.D and P. WERNET, M.D

Department of Anaesthesia Heinrich-Heinc-Uni-versity Moorenstr. 5, D-4000 Dusseldorf 1, Germany
Department of Department of Blood Coagulation and Transfusion Medicine Heinrich-Heinc-Uni-versity Moorenstr. 5, D-4000 Dusseldorf 1, Germany

Correspondence to M.W.

We have examined the effects of commercially available preparations and drug-free so/vents of diazepam (Valium, Diazepam-Lipuro) and midaz-olam (Dormicum) by N-formylmethionyl-leucyl-phenylalanine (FMLP)- and zymosan-induced polymorphonuclear cell (PMN) chemilumines-cence and in a cell-free chemiluminescence system. In the case of Valium, drug-free solvent and diazepam suppressed PMN chemiluminescence. With Diazepam-Lipuro, the so/vent stimulated and diazepam inhibited PMN chemiluminescence. With midazolam (Dormicum), only the active drug depressed PMN chemiluminescence. FMLP-induced PMN chemiluminescence was depressed 10–100 fold more by diazepam and midazolam than zymosan-induced chemiluminescence. (Br. J. Anaesth. 1993; 70: 3177ndash;321)


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