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British Journal of Anaesthesia, 1993, Vol. 70, No. 3 293-297
© 1993 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DICLOFENAC AND KETOPROFEN FOR PAIN TREATMENT AFTER ELECTIVE CASESAREAN SECTION

M. G. F. RORARIUS, M.D, P. SUOMINEN, M.D, G. A. BAER, M.D., PH.D, O. ROMPPANEN, M.D and R. TUIMALA, M.D., PH.D

Department of Anaesthesiology University Hospital P.O. Box 2000, SF-33521 Tampere, Finland
Clinics for Obstetrics and Gynaecology University Hospital P.O. Box 2000, SF-33521 Tampere, Finland

Correspondence to M.G.F.R.

We have studied the effect of a constant infusion of diciofenac 150mg/24h, ketoprofen 200mg/24h or placebo on postoperative pain after elective Caesarean section performed under spinal or extra -dura/block in 90patients in a prospective, randomized and double-blind study. During the first 24 h after operation, patients in the treatment groups were more comfortable than the placebo group (P < 0.005); the diciofenac group needed a mean of oxycodone 21.6 mg/24 h and the ketoprofen group 21.2 mg/24 h, compared with 38.3 mg/24 h in the placebo group (P < 0.001); the mean time to the first injection of oxycodone was 270.5 min in the diciofenac group, 270.2 min in the ketoprofen group and 161.2 min in the placebo group (P < 0.001). During the first 24 h after operation, the temperature increased in the control group by 0.7 °C compared with 0.1 °C in the diciofenac group and 0.3 °C in the ketoprofen group. One patient in the diciofenac group was eliminated from the study because of uterine relaxation during the frst 30 min after start of the drug infusion; this improved after cessation of diciofenac and infusion of sulprostone. There were no other serious side effects. (Br. J. Anaesth. 1993; 70: 293–297)


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