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British Journal of Anaesthesia, 1992, Vol. 69, No. 6 643-644
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia


other

HEPATIC FUNCTION AND INDOCYANINE GREEN CLEARANCE DURING AND AFTER PROLONGED ANAESTHESIA WITH PROPOFOL

J. M. MURRAY, M.B., F.F.A.R.C.S.I. and T. R. TRINICK, M.D., M.R.C.P., M.R.C.PATH.

Departments of Anaesthesia and Biochemistry, The Northern Ireland Regional Plastic Surgery Unit, The Ulster Hospital Belfast BT16 0RH

We have studied the effects of propofol on hepatic function and clearance of indocyanine green (ICG) in 13 consecutive patients undergoing prolonged plastic and reconstructive surgery. Hepatic function was assessed using serum concentrations of liver-specific glutathione-S-transferase (GST). There were no significant changes in GST activity or plasma clearance of ICG throughout the study.


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