British Journal of Anaesthesia, 1992, Vol. 69, No. 6 602-606
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia
research-article |
ISOFLURANE DOES NOT INCREASE THE INCIDENCE OF INTRAOPERATIVE MYOCARDIAL ISCHAEMIA COMPARED WITH HALOTHANE DURING VASCULAR SURGERY
1Abteilung für Klinische Anaesthesiologie, Heinrich-Heine Universitat Dusseldorf, Moorenstr. 5, D-4000 Dflsseldorf 1, F.R. Germany
2Abteilung für Gefässchirurgie und Nicrentransplantion, Heinrich-Heine Universität Düxsseldorf, Moorenstr. 5, D-4000 Dflsseldorf 1, F.R. Germany
We have studied the incidence of new intra-operative myocardial ischaemia (IMI), myocardial infarction (Ml) and cardiac death (CD) in 500 consecutive patients undergoing elective major non-cardiac vascular surgery. Patients were allocated randomly to receive either halothane (n = 226) or isoflurane (n = 274) as principal anaesthetic agent. Using real-time ST segment trend analysis (leads V5 and II) IMI (halothane 39%, isoflurane 38%), MI (halothane 1.3%, isoflurane 1.5%) and CD (halothane 0.4%, isoflurane 0.7%) did not differ significantly between the two groups. Twenty-three per cent of IMI episodes were related to haemodynamic disturbances, but unrelated to the type of surgery: 148 supra-aortic (IMI = 39%), 244 abdominal aortic (IMI = 41%) and 108 lower extremity revascularizations (IMI = 33%). We conclude that the choice of volatile anaesthetic agent does not influence cardiac morbidity or mortality in this type of patient