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British Journal of Anaesthesia, 1992, Vol. 69, No. 6 602-606
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia


research-article

ISOFLURANE DOES NOT INCREASE THE INCIDENCE OF INTRAOPERATIVE MYOCARDIAL ISCHAEMIA COMPARED WITH HALOTHANE DURING VASCULAR SURGERY

K. D. STÜHMEIER, M.D.1, B. MAINZER, M.D.1, W. SANDMANN, M.D.2 and J. TARNOW, M.D.1

1Abteilung für Klinische Anaesthesiologie, Heinrich-Heine Universitat Dusseldorf, Moorenstr. 5, D-4000 Dflsseldorf 1, F.R. Germany
2Abteilung für Gefässchirurgie und Nicrentransplantion, Heinrich-Heine Universität Düxsseldorf, Moorenstr. 5, D-4000 Dflsseldorf 1, F.R. Germany

We have studied the incidence of new intra-operative myocardial ischaemia (IMI), myocardial infarction (Ml) and cardiac death (CD) in 500 consecutive patients undergoing elective major non-cardiac vascular surgery. Patients were allocated randomly to receive either halothane (n = 226) or isoflurane (n = 274) as principal anaesthetic agent. Using real-time ST segment trend analysis (leads V5 and II) IMI (halothane 39%, isoflurane 38%), MI (halothane 1.3%, isoflurane 1.5%) and CD (halothane 0.4%, isoflurane 0.7%) did not differ significantly between the two groups. Twenty-three per cent of IMI episodes were related to haemodynamic disturbances, but unrelated to the type of surgery: 148 supra-aortic (IMI = 39%), 244 abdominal aortic (IMI = 41%) and 108 lower extremity revascularizations (IMI = 33%). We conclude that the choice of volatile anaesthetic agent does not influence cardiac morbidity or mortality in this type of patient


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