Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MICHAEL, S.
Right arrow Articles by REILLY, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MICHAEL, S.
Right arrow Articles by REILLY, C. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 6 577-579
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS OF LIGNOCAINE IN CHILDREN AFTER INFILTRATION FOR CLEFT PALATE SURGERY

S. MICHAEL, M.B., CH.B., F.F.A.R.C.S.I.1, I. BARKER, M.B., CH.B., F.R.C.ANAES.2, P. HENDERSON1, R. W. GRIFFITHS, M.S., F.R.C.S.2 and C. S. REILLY, M.D., F.R.C.ANAES.1

1Department of Anaesthesia, University of Sheffield, Medical School Beech Hill Road, Sheffield S10 2RX
2Children's Hospital, Western Bank Sheffield S10 2TH

We have studied the pharmacokinetics of lignocaine in children after local infiltration for cleft palate surgery. After induction of anaesthesia, lignocaine 2.5 mg kg–1 with adrenaline 1.200000 was injected into the palate. Blood samples were collected before and at 2, 5, 10, 15, 20, 30, 60 and 120 min after infiltration. Plasma concentrations of lignocaine were measured by a gas-liquid chromatographic technique. There were no signs of systemic toxicity on routine monitoring of the patients and the peak plasma concentrations were less than the accepted toxic values. Mean half-life was 72.9 (SEM9.9) min, similar to that found previously in adults and children. However differences in mean clearance (24.6 (2.04) ml kg–1 min–1) and volume of distribution (0.80 (0.07) litre kg–1) were found between this and previous studies.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.