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British Journal of Anaesthesia, 1992, Vol. 69, No. 6 562-566
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECTS OF ISOFLURANE ANAESTHESIA ON THE MEDIAN NERVE SOMATOSENSORY EVOKED POTENTIAL IN CHILDREN{dagger}

D. G. MASON, M.B., B.S., F.R.C.ANAES.1,*, D. HIGGINS, M.B., B.S., F.R.C.ANAES.1,§, S. G. BOYD, M.D.2 and A. R. LLOYD-THOMAS, M.B., B.S., F.R.C.ANAES.1

1Department of Anaesthetics, Hospitals for Sick Children Great Ormond Street, London WC1N 3JR
2Department of Clinical Neurophysiology, Hospitals for Sick Children Great Ormond Street, London WC1N 3JR

Evoked potentials are used to determine the integrity of neural pathways during neurosurgical and orthopaedic procedures, but the extent to which they may be altered by anaesthetic agents has not been studied systematically in children. In this study we have recorded median nerve somato-sensory evoked potentials (mnSSEP) in children during isoflurane anaesthesia to determine if there are changes similar to those seen in adults. We studied 10 patients using standardized anaesthetic and clinical neurophysiological techniques. Control mnSSEP were obtained with 70% nitrous oxide in oxygen and isoflurane was then administered at 0.25, 0.50 and 0.75 MAC. The latencies and amplitudes of the mnSSEP were subjected to repeated measures analysis of the variance (ANOVA) and linear regression. There were statistically significant increases in N20, P22 latencies and central conduction time (P < 0.001) and reductions in amplitude of the N20-P22 complex (P < 0.03) with increasing end-tidal isoflurane concentrations. These results are similar to the findings in adults.

*Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Headington, Oxford, OX3 9DU.

§Department of Anaesthetics, University College Hospital, London, WC1E 6AU.

{dagger}Presented in part at the Anaesthetic Research Society, November 1990 (British Journal of Anaesthesia 1991; 66: 399P)


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