Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by PUTENSEN, C.
Right arrow Articles by HEROLD, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PUTENSEN, C.
Right arrow Articles by HEROLD, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 5 513-516
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

PLASMA LIGNOCAINE CONCENTRATIONS ASSOCIATED WITH EXTRADURAL ANALGESIA IN PATIENTS WITH AND WITHOUT MULTIPLE ORGAN FAILURE

C. PUTENSEN, W. LINGNAU, M.D., G. PUTENSEN-HIMMER, M.D.* and M. HEROLD, PH.D., M.D.

Clinic of Anesthesia and Intensive Care Medicine, University of Innsbruck Austria
Clinic of Internal Medicine, University of Innsbruck Austria

*Address for correspondence: Klinik fur Anasthesie und Allgemeine Intensivmedizin, Anichstrasse 35, A-6020 Innsbruck, Austria.GHRISTIAN PUTENSEN M:D.

We have measured plasma concentrations of ligno-caine after thoracic extradural analgesia with continuous infusion of lignocaine in eight intensive care patients with chest wall trauma or after major upper abdominal surgery. Four patients developed multiple organ failure (MOF). Plasma concentrations of lignocaine in arterial blood were measured 4, 8, 24 and 48 h after a continuous infusion of lignocaine was commenced in the extradural space. Plasma concentrations of lignocaine were greater in all patients with MOF (range 2.7–5.1 ng ml–1) than in patients without MOF (range 0.8–1.2 fig mh–1). Because plasma concentrations in patients with MOF were within the low toxic range, extradural infusion of lignocaine should only be considered in intensive care patients without MOF or when plasma concentrations of lignocaine are monitored. (Br. J. Anaesth. 1992;69:513–516)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.