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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 511-512
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ONSET AND RECOVERY OF ROCURONIUM (ORG 9426) AND VECURONIUM UNDER ENFLURANE ANAESTHESIA

M. MAYER, M.D., A. DOENICKE, M.D., A. HOFMANN and K. PETER, M.D.

Institute of Anaesthesiology, LMU München, Innenstadtkliniken, Nußbaumstr 20, 8000 Munchen 2, Germany

We have studied the onset, duration of action and recovery index of twice the ED90 of rocuronium (Org 9426) (0.6 mg kg–1) and of vecuronium (0.08 mg kg–1) in patients during enf/urane anaesthesia. Rocuronium had a significantly shorter mean onset time of 1.8 (SD 0.4) min, compared with vecuronium 3.4 (0.8) min. Clinical duration (time for the first twitch in the train-of-four to recover to 25% of control) was similar for both drugs (29 (10) min vs 31 (12) min). Spontaneous recovery times (TOF ratio 70%) did not differ significantly between rocuronium (47 (10) min) and vecuronium (44 (11) min). (Br. J. Anaesth. 1992;69:511–512)


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