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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 508-510
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

other

IN VITRO DISPLACEMENT OF VASOACTIVE MEDIATORS FROM PLASMA PROTEINS: A POSSIBLE MECHANISM FOR PSEUDO-ALLERGIC REACTIONS TO NEUROMUSCULAR BLOCKING DRUGS

W. R. WILLIAMS, PH.D. and D. J. SHALE, B.SC, M.D., F.R.C.P.

University of Wales College of Medicine, Section of Respiratory Medicine, Llandough Hospital Penarth, South Glamorgan CF6 1XX

We have studied the re/ease of prostaglandin F2{alpha} (PGF2{alpha} and histamine from serum proteins by neuromuscular blocking drugs using equilibrium dialysis, with tracer quantities of radio-labelled mediators as probes. Small concentrations (0.05–0.25 mmol litre–1) of competitive neuromuscular blocking drugs displaced 16–67% of bound histamine. Greater concentrations of suxamethonium (2 mmol litre–1) were required for histamine displacement (19%). There was a significant release of PGF2* by atracurium 1 mmol litre–1 and pan–curonium 0.69 mmol litre–1. These findings suggest an alternative mechanism of histamine release by neuromuscular blocking drugs which may be relevant to adverse reactions during use. (Br. J. Anaesth. 1992;69:508–510)


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