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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 471-473
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EVALUATION OF SPIN RESONANCE SPECTROSCOPY OF RED BLOOD CELL MEMBRANES TO DETECT MALIGNANT HYPERTHERMIA SUSCEPTIBILITY

P. J. HALSALL, M.B., CH.B.1, F. R. ELLIS, M.B., CH.B., PH.D., F.R.C.ANAES.1 and P. F. KNOWLES, B.SC., PH.D.2

1The Leeds MH Investigation Unit, University Department of Anaesthesia, St James's University Hospital Leeds LS9 7TF
2Department of Biochemistry and Molecular Biology, University of Leeds

We have evaluated a spin labelled electron spin resonance technique to identify malignant hyper-thermia susceptible (MHS) patients. We studied 19 patients, 10 MHS and nine MHN (normal), using the standard European procedure. We were unable to obtain any evidence that this technique could be used to diagnose MH susceptibility. Furthermore, there was no significant difference in the fluidity of the red blood cell membranes between the two groups, which would have been indicative of a generalized membrane abnormality in MH. (Br. j. Anaesth. 1002;69:471–473)


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