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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 468-470
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia


research-article

IS THE "K-TYPE" CAFFEINE-HALOTHANE RESPONDER SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA ?

F. R. ELLIS, M.B., CH.B., PH.D., F.R.C.ANAES., P. J. HALSALL, M.B., CH.B. and P. M. HOPKINS, M.B., B.S., F.R.C.ANAES.

The Leeds Malignant Hyperthermia Investigation Unit, Academic Unit of Anaesthesia, St James's University Hospital Leeds LS9 7TF

The "K-type" designation is used to describe a patient being investigated for malignant hyper-thermia (MH) when concurrent administration of caffeine and halothane induces muscle contracture (rigidity, spasm) in vitro, but when halothane and caffeine given separately produce a normal response. It is accepted in some centres that K-type individuals are susceptible to malignant hyper-thermia (MHS). In this paper, the K-type is shown not to correlate with the MH susceptible (MHS) status as accepted by the European MH group.


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