Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by POWER, I.
Right arrow Articles by PUGH, G. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by POWER, I.
Right arrow Articles by PUGH, G. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 5 451-456
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF DICLOFENAC ON RENAL FUNCTION AND PROSTACYCLIN GENERATION AFTER SURGERY

I. POWER, M.D., F.R.C.ANAES.1,*, A. D. CUMMING, M.D.2 and G. C. PUGH, F.R.C.ANAES.3

1University Department of Anaesthetics, Royal Infirmary of Edinburgh Edinburgh
2University Department of Medicine, Medical Renal Unit, Royal Infirmary of Edinburgh Edinburgh
3Department of Anaesthetics, City Hospital Edinburgh

We have examined the effect of diclofenac on renal function after major surgery in a randomized, double-blind, controlled study of 20 patients undergoing oesophagogastrectomy. Diclofenac 75 mg or placebo was given i.m. 12-hourly for 2 days. l.v. fluid administration was standardized. Renal function was assessed by fluid balance and measurement of serum creatinine and electrolyte concentrations, creatinine and free water clearance, and urinary sodium and potassium excretion. Urinary 6-keto-prostaglandin F1{alpha}(6-keto-PGF1{alpha} was measured by radioimmunoassay to assess renal prostacyclin production. After surgery, 6-keto-PGF1{alpha} production increased, but this did not occur with diclofenac. On the first day after surgery, use of diclofenac was associated with a decreased urine flow rate, decreased urinary sodium and potassium excretion and a tendency to hyperkalaemia. Fruse-mide was required more often in the diclofenac group. One patient was withdrawn from the diclofenac group because of impaired renal function. Urine flow rate and blood potassium concentration should be monitored if diclofenac is used after major surgery (Br. J. Anaesth. 1992; 69: 451–456)

*Present address, for correspondence: Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
H. Kim, M. Xu, Y. Lin, M. J. Cousins, R. P. Eckstein, V. Jordan, I. Power, and L. E. Mather
Renal Dysfunction Associated with the Perioperative Use of Diclofenac
Anesth. Analg., October 1, 1999; 89(4): 999 - 999.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.