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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 444-446
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ETOMIDATE SHORTENS THE ONSET TIME OF NEUROMUSCULAR BLOCK

R. S. GILL, B.M., F.R.C.ANAES.* and R. P. F. SCOTT, B.SC, M.B., CH.B., F.R.C.ANAES., M.D.1

Department of Anaesthesia, Odstock Hospital Salisbury, Wiltshire

1Correspondence to R.P.F.S.

We have studied 30 healthy patients allocated randomly to receive thiopentone, propofol or etomidate in equipotent doses followed by vecu-ronium 0.1 mg kg–1. Haemodynamic variables and time to 100% neuromuscular block were measured. The patients receiving etomidate had a significantly shorter onset time of neuromuscular block compared with those receiving the two other i.v. induction agents. There was a significant negative correlation between onset time of neuromuscular block and the maximum percent change in mean arterial pressure. (Br. J. Anaesth. 1992; 69: 444–446)

*Present address: Critical Care Programme, University Hospital, University of W. Ontario, London, Ontario, Canada.


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