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British Journal of Anaesthesia, 1992, Vol. 69, No. 5 439-443
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF AGE, SEX AND ANAESTHETIC TECHNIQUE ON THE PHARMACOKINETICS OF ATRACURIUM

C. J. R. PARKER, M.A., M.D., F.R.C.ANAES., J. M. HUNTER, M.B., F.R.C.ANAES. and S. L. SNOWDON, M.B., CH.B., F.R.C.ANAES.

University Department of Anaesthesia, 4th Floor, Royal Liverpool Hospital Prescot Street, P.O. Box 147, Liverpool L69 3BX

We have defined the pharmacokinetics of atra-curium besylate 0.25 mg kg–1 in 41 patients anaesthetized with 0.9% isoflurane end-tidal, 0.5% halothane end-tidal or midazolam 3–10 mg as a supplement to 66% nitrous oxide in oxygen. The pharmacokinetic profile was affected by age, sex and anaesthetic technique. Advancing age was associated with a reduced clearance and a longer elimination half-time; clearance was greater and elimination half-time was shorter in males than in females. Clearance was also greater in patients anaesthetized with isoflurane than with the two other techniques. Age, sex and anaesthetic technique did not significantly affect the volume of distribution. (Br. J. Anaesth. 1992; 69: 439–443)


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