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British Journal of Anaesthesia, 1992, Vol. 69, No. 4 382-386
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PORCINE MODEL FOR STUDYING THE PASSAGE OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKERS THROUGH THE BLOOD-BRAIN BARRIER

A. WERBA, M.D., H. GILLY, PH.D., M WEINDLMAYR-GOETTEL, PH.D., C. K. SPISS, M.D., K. STEINBEREITHNER, M.D., T. CZECH, M.D. and S. AGOSTON, M.D.

Clinic of Anaesthesia and General Intensive Care Medicine, University of Vienna Spitalgasse 23, A-1090 Vienna, Austria.
Ludwig Boltzmann Institute of Experimental Anaesthesiology and Research in Intensive Care Medicine Spitalgasse 23, A-1090 Vienna, Austria.
Clinic of Neurosurgery, University of Vienna Wahringer Gurtel 18–20, A-1090 Vienna, Austria.
Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen Oostersingel 59, 9713 EZ Groningen, The Netherlands.

A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebellomedullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.


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