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British Journal of Anaesthesia, 1992, Vol. 69, No. 4 375-381
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF GRADED INFUSION RATES OF PROPOFOL ON REGIONAL AND GLOBAL LEFT VENTRICULAR FUNCTION IN THE DOG{dagger}

R. M. PUTTICK, M.SC., D.PHIL,, J. DIEDERICKS, B.M., B.A., M.MED. (ANAES.), F.F.A.(S.A.)*, J. W. SEAR, M.A., B.SC., M.B., B.S., PH.D., F.R.C.ANAES., P. FOËX, M.A., D.PHIL., D.M. (GENEVA), F.R.C.ANAES., W. A. RYDER and J. B. GLEN, B.V.M.S., PH;D,D.V.A.

Department of Pharmacology, University of Oxford Oxford
Nuffield Department of Anaesthetics, Radcliffe Infirmary Oxford OX2 6HE.
Medical Research Department, ICI Pharmaceuticals Alderley Park, Macclesfield, Cheshire.

Correspondence to P.F.

We have studied the effects of graded infusion rates of propofol (0.2–0.5 mg kg–1 min–1) on left ventricular global and regional function, in eight acutely instrumented dogs. Global function was assessed by measurement of aortic and left ventricular pressure, L V dP/dtmax, aortic blood acceleration and stroke volume. Regional function was assessed by measurement of systolic shortening and the endsystolic pressure-length relationship. The response of the coronary circulation to short periods of occlusion was also assessed. Administration of propofol significantly reduced left ventricular preload, as indicated by reductions in end-diastolic pressure and length; contractility was depressed, the depression being greater in the apex than in the base of the left ventricle. High infusion rates impaired relaxation. Regulation of coronary blood flow was not disrupted. Reductions in preload and contractility contributed to the propofol-induced hypotension. After 60 min, recovery from the greatest infusion rate was incomplete.

*Present address: Department of Anaesthesiology, University of the Orange Free State, Bloemfontein, SA.

{dagger}Abstract presented at the 11th Annual Meeting of the European Academy of Anaesthesiology, Bonn, Germany, September 1989.


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