Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by LAYCOCK, G. J. A.
Right arrow Articles by MORTON, N. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAYCOCK, G. J. A.
Right arrow Articles by MORTON, N. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 4 356-362
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EEG BURST SUPPRESSION WITH PROPOFOL DURING CARDIOPULMONARY BYPASS IN CHILDREN: A STUDY OF THE HAEMODYNAMIC, METABOLIC AND ENDOCRINE EFFECTS

G. J. A. LAYCOCK, F.R.C.ANAES., D.C.H., D.R.C.O.G., J. M. MITCHELL, F.R.C.S.*, R. D. PATON, PH.D., S. F. O'B. DONAGHEY, PH.D, R. W. LOGAN, F.R.C.P.(GLAS.)., F.R.C.PATH. and N. S. MORTON, F.R.C.ANAES.

Department of Anaesthetics Yorkhill, Glasgow G3 8SJ
Department of Cardiac Surgery Yorkhill, Glasgow G3 8SJ
Department of Biochemistry Yorkhill, Glasgow G3 8SJ
Royal Hospital for Sick Children Yorkhill, Glasgow G3 8SJ

Correspondence to N.S.M.

We have studied the effects of propofol, given to maintain EEG suppression throughout cardiopulmonary bypass (CPB), in 20 children aged 1-15 yr, in a parallel group comparison. Anaesthesia was produced by fentanyl 50µg kg–1, enflurane or halothane and midazolam 0.1 mg kg–1 at the start of CPB. After randomization, 50% of the children also received propofol during CPB. All children were cooled during CPB (25–28 °C) and pump flows (non-pulsatile) were 2.4 litre min–1 m–2, reducing to 1.2–1.6 litre min–1 m–2 during hypothermia. Large rates of infusion of propofol were required to maintain EEG suppression, particularly during rewarming. Compared with control, the propofol group showed significant increases in mixed venous oxygen saturation and significant reductions in systemic oxygen uptake and glucose and cortisol concentrations. There were no differences in triiodothyronine and lactate concentrations, mean arterial pressure during CPB and inotrope requirement after CPB, or in recovery times.

*Present address: Department of Cardiac Surgery, Killingbeck Hospital, York Road, Leeds LSI4 6UQ.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
J. LeBlanc, D Blackstock, A. Macnab, F Gagnon, R Gagnon, J Russell, and T Ring
Effects of propofol on cerebral oxygenation during cardiopulmonary bypass in children
Can J Anesth, November 1, 2000; 47(11): 1082 - 1089.
[Abstract]

Home page
 Anesth. Analg.Home page
G. D. Williams, T. K. Jones, K. A. Hanson, and J. P. Morray
The Hemodynamic Effects of Propofol in Children with Congenital Heart Disease
Anesth. Analg., December 1, 1999; 89(6): 1411 - 1411.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.