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British Journal of Anaesthesia, 1992, Vol. 69, No. 2 200-201
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE IMPORTANCE OF ACTIVITY AND PRETREATMENT IN THE PREVENTION OF SEXUAMETHONIUM MYALGIAS

D. C. OXORN, M.D., C.M., F.R.C.P.C.*, G. S. WHATLEY, M.D., F.R.C.P.C.J., J. W. D. KNOX, M.B., F.R.C.ANAES. and J. HOOPER, M.D., F.R.C.P.C.

Department of Anaesthesia, Camp Hill Medical Centre 1335 Queen Street, Halifax, Nova Scotia, Canada B3J 2H6

*Present address, for correspondence: Department of Anaesthesia, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5

We have studied the effectiveness of pretreatment with atracurium 0.05 mg kg–1 and placebo before administration of suxamethonium, in the prevention of postoperative myalgia in inpatients having surgery in which rapid postoperative mobilization was possible (vaginal hysterectomy). On the second day after operation, the patients pretreated with atracurium had significantly fewer postoperative myalgias than those receiving placebo (P < 0.025). All patients were significantly more active on the second day compared with the first day after operation (P < 0.025). Possible causal relationships are discussed.


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