Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (32)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by PRICE, M. L.
Right arrow Articles by CASHMAN, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PRICE, M. L.
Right arrow Articles by CASHMAN, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 2 172-176
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CHANGES IN CARDIAC INDEX AND ESTIMATED SYSTEMIC VASCULAR RESISTANCE DURING INDUCTION OF ANAESTHESIA WITH THIOPENTONE, METHOHEXITONE, PROPOFOL AND ETOMIDATE

M. L. PRICE, B.SC., M.B., B.S., F.R.CANAES.*, B. MILLAR, B.A., R.G.N., M. GROUNDS, M.D., P.R.CANAES. and J. CASHMAN, B.SC, M.B., B.S., F.R.CANAES.

Department of Anaesthetics, St Georges Hospital Blackshaw Road, London SW17 0QT

*Address for correspondence: Department of Anaesthetics, St Mary's Hospital, London W2 1NY.

Changes in cardiac index (Cl) and estimated systemic vascular resistance (ESVR) were assessed non-invasively using pulsed Doppler ultrasound during induction of anaesthesia. Ninety-six ASA I patients were allocated randomly to one of four groups to receive alfentanil 8 µg kg1 followed by a dose of thiopentone, methohexitone, propofol or etomidate sufficient to obtund the eyelash reflex. Cl increased significantly by 8% 1 min after administration of both methohexitone (? < 0.05) and propofol (P < 0.05), returning to pre-induction values thereafter. Cl increased after thiopentone but the increase was not statatistically significant. There was a significant decrease in Cl of 16% after induction with etomidate (P < 0.001). ESVR decreased significantly from pre-induction values by 18% after methohexitone (P < 0.001) and 23% after propofol (P < 0.001). ESVR in the thiopentone group decreased, but this was not statistically significant. ESVR increased significantly by 12% 1 min after induction of anaesthesia with etomidate (P < 0.05) and then decreased towards pre-induction values. The results suggest that the cardiostability of etomidate may not be as complete in all groups of patients as previous studies have suggested.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Sarkar, P. C. Laussen, D. Zurakowski, A. Shukla, B. Kussman, and K. C. Odegard
Hemodynamic Responses to Etomidate on Induction of Anesthesia in Pediatric Patients
Anesth. Analg., September 1, 2005; 101(3): 645 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. B. Johnson, T. D. Egan, J. Layman, S. E. Kern, J. L. White, and S. W. McJames
The Influence of Hemorrhagic Shock on Etomidate: A Pharmacokinetic and Pharmacodynamic Analysis
Anesth. Analg., May 1, 2003; 96(5): 1360 - 1368.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.