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British Journal of Anaesthesia, 1992, Vol. 69, No. 2 159-161
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THROMBELASTOGRAPHY AFTER ASPIRIN INGESTION IN PREGNANT AND NON-PREGNANT SUBJECTS

C. E. P. ORLIKOWSKI, F.R.C.ANAES.1,*, A. J. PAYNE, M.B., CH.B.2, J. MOODLEY, F.C.O.G.(S.A.), F.R.C.O.G.(U.K.),M.D.(NATAL)2 and D. A. ROCKE, M.R.C.P. (U.K.), F.F.A.(S.A.)1,{dagger}

1Department of Anaesthetics, Faculty of Medicine, University of Natal Durban, South Africa
2Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Natal Durban, South Africa

{dagger}Address for correspondence: University of Natal, Faculty of Medicine, Department of Anaesthetics, PO Box 17039, Congella 4013, Durban, South Africa.

The thrombelastograph (TEG) and bleeding time were performed before and 6 h after a single oral dose of aspirin 600 mg in a group of eight healthy volunteers and 12 pregnant patients. Measured TEG variables (r, k, r + k times and maximum amplitude) were unaltered after aspirin although there was a significant prolongation of the bleeding time in both groups. Although the TEG appeared not to detect aspirin-induced changes in platelet function, the TEG measures all phases of coagulation and the unaltered TEG after aspirin suggested a functioning coagulation system.

*Present address: Department of Anaesthetics, Royal Sussex County Hospital, Brighton BN25 BE.


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