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British Journal of Anaesthesia, 1991, Vol. 67, No. 1 79-83
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PREANAESTHETIC MEDICATION WITH CLONIDINE: A DOSE-RESPONSE STUDY

U. A. CARABINE, M.B., B.CH., F.F.A.R.C.S.I., P. M. C. WRIGHT, M.B., B.CH., F.F.A.R.C.S.I. and J. MOORE, M.D., PH.D., F.C.ANAES.

Department of Anaesthetics, The Queen's University Belfast Whitla Medical Building, 97 Lisburn Rd, Belfast BT9 7BL

Correspondence to U.A.C.

Eighty normotensive female patients were studied in a randomized, double-blind investigation, in which orally administered clonidine 0.1 mg, 0.2 mg and 0.3 mg were compared with a standard benzodiazepine premedicant. Clonidine 0.2 mg produced a significant reduction in anxiety (P < 0.05) compared with all the other groups, and a better quality of induction of anaesthesia when compared with temazepam 20 mg and clonidine 0.1 mg. The decreases in arterial pressure and heart rate with clonidine 0.3 mg were significant compared with the other treatment groups. Hypotension persisted into the postoperative period after premedication with clonidine 0.3 mg, and this dose is not recommended as a routine premedicant.


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