British Journal of Anaesthesia, 1991, Vol. 66, No. 3 353-357
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia
research-article |
CLONIDINE DOES NOT DELAY RECOVERY FROM ANAESTHESIA
Département d'Anesthésie Réanimation, Hôpital Henri Mondor 51 av. du Maréchal de Lattre de Tassigny, 94010 Creteil Cedex, France
INSERM, U138, Faculté de Médecine Creteil, France
Correspondence to F.B.
Clonidine is known to reduce anaesthetic requirements and improve haemodynamic stability when given as premedication. This study, of 46 ASA III patients undergoing thyroid surgery, was designed to assess if clonidine interferes with recovery from anaesthesia. Patients were allocated randomly to three groups to receive, 2 h before surgery, flunitrazepam 1 mg, clonidine 150 µg, or both drugs. Anaesthesia comprised thiopentone, alfentanil, isoflurane and 70% nitrous oxide in oxygen. Recovery from anaesthesia was assessed using a clinical score, electro-oculographic measurements and reaction times to auditory stimuli. Psychomotor tests were performed the day before surgery and 30, 60, 120 and 240 min after arrival of the patient in the recovery room. Psychomotor performance was decreased significantly after operation in the three groups (P<0.05) and returned to baseline at 240 min. There was no significant difference between the three groups. This study indicates that clonidine 150 µg orally before surgery does not delay recovery from anaesthesia.
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