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British Journal of Anaesthesia, 1991, Vol. 66, No. 3 324-326
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

OPTIMAL DOSE OF LIGNOCAINE FOR PREVENTING PAIN ON INJECTION OF PROPOFOL

G. GEHAN, M.D., P. KAROUBI, M.D., F. QUINET, M.D., A. LEROY, M.D., C. RATHAT, M.D. and J. L. POURRIAT, M.D.*

Département d'Anesthésie-Réanimation, CHU Avicenne-Jean Verdier, Université Paris XIII Bobigny, France

*Address for correspondence: Département d'Anesthésie-Réanimation, Hôpital Jean Verdier, 93140 Bondy, France

The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol. We conducted a prospective, randomized, double-blind trial on 310 patients undergoing anaesthesia. Patients were allocated to four groups according to the lignocaine dosage: group A (control), no lignocaine; group B, lignocaine 0.1 mg kg–1; group C, lignocaine 0.2mgkg–1; group D, lignocaine 0.4mg kg–1. Our results showed that a dose of lignocaine 0.1 mg kg–1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased.


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