Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HOSIE, H. E.
Right arrow Articles by NIMMO, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOSIE, H. E.
Right arrow Articles by NIMMO, W. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1991, Vol. 66, No. 1 20-24
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

TEMAZEPAM ABSORPTION IN PATIENTS BEFORE SURGERY

H. E. HOSIE, M.B., CH.B., F.C.ANAES.* and W. S. NIMMO, B.SC., M.D., F.R.C.P., F.C.ANAES., F.F.A.R.A.C.S.{dagger}

Department of Anaesthesia, University of Sheffield Sheffield S10 2RX

We have compared the rates of absorption and efficacies of temazepam 30 mg in elixir and capsule formulations in 100 patients before surgery. Both formulations provided anxiolysis and sedation, but there was wide variation in plasma concentrations of temazepam between individuals and between formulations. The presence or absence of anxiety did not influence the absorption of the preparations. It is suggested that plasma concentrations in excess of 200 ng ml–1 are required for sedation and anxiolysis, and that this may be achieved more reliably using the elixir formulation.

*Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF.

{dagger}Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.