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British Journal of Anaesthesia, 1991, Vol. 66, No. 1 138-140
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

MUSCLE BIOPSY FOR DIAGNOSIS OF MALIGNANT HYPERTHERMIA SUSCEPTIBILITY IN TWO PATIENTS WITH SEVERE EXERCISE-INDUCED MYOLYSIS

W. HACKL, M.D.*, M. WINKLER, M.D., W. MAURITZ, M.D., P. SPORN, M.D. and K. STEINBEREITHNER

MH-Investigation Unit of the Ludwig Boltzmann Institute of Experimental Anaesthesiology and Research in Intensive Care Medicine Spitalgasse 23, A-1090 Vienna, Austria
Department of Anaesthesiology, Krankenanstalt Rudolfstiftung Juchgasse 25, A-1030 Vienna, Austria

*Address for correspondence: University Department of Anaesthesiology and Intensive Care Medicine, Vienna Medical School, Spitalgasse 23, A-1090 Vienna, Austria.

Muscle biopsy and in vitro contracture tests for diagnosis of susceptibility to malignant hyperthermia (MH) were performed in two patients who had developed fever and severe myolysis during exercise. MH susceptibility was confirmed in one patient but in the other, exercise-induced heat stroke proved to be the correct diagnosis. Clinical presentation and epidemiology of exercise-induced MH and its relation to the heat stroke syndrome are discussed.


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