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British Journal of Anaesthesia, 1991, Vol. 66, No. 1 108-115
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF CLONIDINE ON THE CIRCULATION AND VASOACTIVE HORMONES AFTER AORTIC SURGERY

L. QUINTIN, M.D., PH.D.*, F. ROUDOT, M.D., M.SC., C. ROUX, M.D., I. MACQUIN, M.D., A. BASMACIOGULLARI, B.SC., T. GUYENE, M.D., M. VAUBOURDOLLE, M.D., J. P. VIALE, M.D., F. BONNET, M.D. and M. GHIGNONE, M.D., F.R.C.P.C.

Department of Anesthesiology, CHU Mondor, Créteil and Laboratory of Environmental Physiology, Grange-Blanche School of Medicine Lyons, France

*Address for correspondence: Laboratory of Environmental Physiology, Grange-Blanche School of Medicine, 69373 Lyons, France.

After completion of abdominal aortic graft, 29 patients received an i.v. infusion of placebo (n = 16) or clonidine 7 µg kg–1 (n = 13) over 120 min in a double-blind study. Cardiovascular variables were measured and plasma samples obtained up to 5 h after arrival in the recovery room, for assay of noradrenaline, adrenaline, vasopressin and renin concentrations. Noradrenaline, adrenaline and vasopressin concentrations decreased in the clonidine group throughout recovery (P < 0.001, 0.05 and 0.05, respectively, vs placebo). Heart rate was less in the clonidine group (P < 0.01). There was no significant difference in mean arterial pressure between groups. Stroke volume was larger (P < 0.01) and there were fewer episodes of hypertension (P < 0.05) and tachycardia in the clonidine group. In addition, a reduction in the number of circulatory interventions (P < 0.05) and episodes of shivering was noted in the clonidine group. Mean (SD) postoperative volume requirements were larger in the clonidine group (total postoperative input: clonidine 1462 (604) ml; placebo 1064 (348) ml (P < 0.05)). These data are consistent with the observation that clonidine modifies endocrine and circulatory status after major surgery.


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