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British Journal of Anaesthesia, 1991, Vol. 66, No. 1 103-107
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DISPOSITION OF MORPHINE-6-GLUCURONIDE AND MORPHINE IN HEALTHY VOLUNTEERS

M. H. HANNA, F.C.ANAES., S. J. PEAT, B.SC., F.C.ANAES., A. A. KNIBB, F.C.ANAES. and C. FUNG, PH.D.

Pain Relief Research Unit, Kings College Hospital, School of Medicine and Dentistry Denmark Hill, London SE5 9RS

Correspondence to M. H. H.

The pharmacokinetics and subjective side effects of i.v. morphine sulphate 120 µg kg–1 and morphine-6-glucuronide (M6G) 30 µg kg–1 were determined in six healthy volunteers, using a placebo-controlled, single-blind randomized crossover design. Five of these volunteers underwent an additional (non-randomized) study of M6G 60 µg kg–1. Subjective side effects were similar following both drugs, but of shorter duration following M6G. Morphine was not detected after administration of M6G. For M6G 30 µg kg–1 the mean (SD) volume of distribution, elimination half-life and clearance were 29.38 (18.36) litre, 2.05 (1.2) h and 187.81 (37.41) litre h–1, respectively. These values were not significantly different from those obtained for M6G 60 µg kg–1. In all subjects the volumes of distribution and clearances were significantly smaller for M6G than for morphine, but the elimination half-lives were similar.


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