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British Journal of Anaesthesia, 1990, Vol. 64, No. 1 59-63
© 1990 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ANTICONVULSANT PROPERTIES OF PROPOFOL AND THIOPENTONE: COMPARISON USING TWO TESTS IN LABORATORY MICE

S. LOWSON, M.B., B.S., B.SC., M.R.C.P., F.C.ANAES., J. P. GENT, M.A., PH.D. and C. S. GOODCHILD, M.A., M.B., B.CHIR., PH.D., F.F.A.R.C.S.

Department of Anaesthesia, Leeds General Infirmary Leeds
Department of Pharmacology, University of Leeds Leeds
Department of Anaesthesia, University of Leeds 24 Hyde Terrace, Leeds LS2 9LN

Correspondence to C.S.G.

Experiments were carried out in mice to assess the protection provided by thiopentone (Intraval, May and Baker) and propofol (Diprivan, I.C.I.) against epileptiform seizures induced by electro-shock and pentylenetetrazol. Intraperitoneal administration of propofol 50 mg kg–1 and thiopentone 25 mg kg–1 produced similar peak behavioural effects of mild sedation and incoordination. However, at these doses propofol afforded a greater degree of protection against pentylenetetrazol than thiopentone and at greater doses both propofol and thiopentone caused marked protection. Both anaesthetics were effective also against electroshock seizures at sedative doses. We conclude that propofol has strong anticonvulsant properties.


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