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British Journal of Anaesthesia, 1990, Vol. 64, No. 1 16-20
© 1990 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DOUBLE BLIND COMPARISION OF TRANSDERMAL HYOSCINE AND PLACEBO FOR THE PREVENTION OF POSTOPERATIVE NAUSEA

E. M. J. KOSKI, M.D., M. A. K. MATTILA, M.D., PH.D., D. KNAPIK, M.D., T. TOIVANEN, M.D., H. RUUSUKALLIO, M.D., P. ANDERSSON and Y. FREUDENTHAL

Kuopio University Central Hospital SF-70210 Kuopio, Finland
District Hospital of Varkaus SF-78300 Varkaus, Finland
Ciba-Geigy Oy SF-00240, Helsinki, Finland

Transdermal hyoscine (Scopoderm, Ciba-Geigy) has been compared with placebo in 283 female patients. The hyoscine patch had no significant effect on postoperative nausea or vomiting. In contrast with earlier studies, there was no correlation between previous experiences of nausea (motion, pregnancy or surgery related) and nausea caused by the surgery or anaesthetic in this study. No correlation was found between nausea or vomiting and the type of operation.


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