British Journal of Anaesthesia, 1990, Vol. 64, No. 1 107-109
© 1990 The Board of Management and Trustees of the British Journal of Anaesthesia
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SERUM CONCENTRATIONS OF PRILOCAINE FOLLOWING RETROBULBAR BLOCK
Department of Ophthalmology St Vincent's Hospital, Dublin 4
Department of Anaesthesia & Critical Care Medicine St Vincent's Hospital, Dublin 4
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland St Stephens Green, Dublin 2
Retrobulbar block for eye surgery is associated with adverse reactions. We performed retrobulbar block in 10 patients using prilocaine (Citanest) and found mean (SD) peak serum concentrations of 851 (165.6) ng ml1 (range 5401100 mg ml1). Peak serum concentrations occurred 37 min after the end of administration of the block, and in all cases were less than those associated with toxicity.