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British Journal of Anaesthesia, 1989, Vol. 63, No. 5 601-603
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF THE CARDIORESPIRATORY EFFECTS OF KETOROLAC AND ALFENTANIL DURING PROPOFOL ANAESTHESIA

A. W. MURRAY, M.B., CH.B., F.F.A.R.C.S., M. S. BROCKWAY, M.B., CH.B., F.F.A.R.C.S.*, and G. N. C. KENNY, B.SC. (HONS), M.D., F.F.A.R.C.S.

University Department of Anaesthesia, Royal Infirmary Glasgow G31 2ER
Division of Anaesthesia, Royal Infirmary Glasgow G31 2ER

Correspondence to A.W.M.

The cardiorespiratory effects of a new nonopioid analgesic, ketorolac tromethamine, were compared with alfentanil as part of a balanced technique in which anaesthesia was maintained by a constant infusion of propofol. Twenty patients were allocated randomly to receive a single dose of either ketorolac 30 mg or alfentanil 0.5 mg. The study medication was given during the anaesthetic when the rate of ventilation had been stable (±1 b.p.m.) for 5 min. Measurements of ventilatory rate, end-tidal carbon dioxide partial pressure, arterial oxygen saturation (SaO2), heart rate and systemic arterial pressure were made at 1-min intervals for 15 min following the test drug. Patients having alfentanil developed significant decreases in ventilatory rate, heart rate and mean arterial pressure. A significant increase in end-tidal carbon dioxide partial pressure occurred also. No changes occurred in any of the measured variables in the ketorolac group.

*Present address: Royal Infirmary, Edinburgh.


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