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British Journal of Anaesthesia, 1989, Vol. 63, No. 5 536-540
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF I.V. OMEPRAZOLE ON THE pH AND VOLUME OF GASTRIC CONTENTS BEFORE SURGERY

R. H. CRUICKSHANK, M.B., B.S., F.F.A.R.C.S.*, D. A. MORRISON, B. MED SCI., P. A. BAMBER, M.B., CH.B., F.F.A.R.C.S.{dagger} and W. S. NIMMO, M.D., B.SC., M.R.C.P., F.F.A.R.C.S.{ddagger}

Department of Anaesthesia, University of Sheffield Sheffield S10 2RX
*Department of Anaesthetics, Leeds General Infirmary Leeds LSI 3EX
{dagger}Department of Anaesthetics, St James's University Hospitals Leeds LS9 7TF
{ddagger}Inveresk Research International Musselburgh, Scotland EH21 7 UB

Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume than administration 3 h before surgery. There was a reduction in the number of patients with a pH of less than 2.5 and a volume of 25 ml or more in the treated groups compared with the combined placebo groups. Omeprazole may have a role in prophylaxis against acid aspiration syndrome.


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