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British Journal of Anaesthesia, 1989, Vol. 63, No. 5 525-530
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CONCENTRATIONS OF ATRACURIUM AND LAUDANOSINE IN CEREBROSPINAL FLUID AND PLASMA DURING INTRACRANIAL SURGERY

J. M. EDDLESTION, M.B., CH.B., F.F.A.R.C.S., N. J. N. HARPER, M.B., CH.B., F.F.A.R.C.S., B. J. POLLARD, B.PHARM., M.B., CH.B., F.F.A.R.C.S., D. EDWARDS, B.SC. and C. L. GWINNUTT, M.B., B.S., F.F.A.R.C.S.

Department of Anaesthesia, Hope Hospital Eccles Old Road, Salford M6 8HD
Department of Anaesthesia, Manchester Royal Infirmary Oxford Road, Manchester

Correspondence to C.L.G.

Concentrations of atracurium and laudanosine in cerebrospinal fluid (CSF) and plasma were assayed in nine patients receiving atracurium infusions of 111–251 min duration to maintain neuromuscular block during intracranial surgery. The total dose of atracurium was 1.57–2.60 mg kg–1 and the plasma concentration of atracurium was 1.27–5.44 µg ml–1. Concentrations of laudanosine in CSF and plasma increased during the infusion period, and after 125–140 min reached means of 202.5 ng ml–1 and 1448.7 ng ml–1, respectively. The highest recorded concentration of laudanosine in CSF was 570 ng ml–1, in one of two CSF samples found to contain atracurium. After operation, two patients had fits, but these were not thought to be related to laudanosine. It is concluded that during infusion of atracurium, laudanosine accumulates in both plasma and CSF.


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