Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MCKENZIE, J. D.
Right arrow Articles by NIMMO, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MCKENZIE, J. D.
Right arrow Articles by NIMMO, W. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1989, Vol. 63, No. 4 489-491
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

A MODEL TO TEST THE POTENCY OF INHALATION ANAESTHETICS

J. DOUGLAS MCKENZIE, B.SC., M.SC., PH.D., PETER CALOW, B.SC., PH.D., D.SC., C.BIOL., F.I.BIOL. and WALTER S. NIMMO, B.SC. (MED.SCT.), M.D., F.R.C.P., F.F.A.R.C.S.*,

Department of Animal and Plant Sciences, University of Sheffield Sheffield S10 2TN
Department of Anaesthesia, University of Sheffield Beech Hill Road, Sheffield S10 2RX

Present address: Inveresk Clinical Research, Research Park, Riccarton, Edinburgh EH14 4AP.

The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.