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British Journal of Anaesthesia, 1989, Vol. 63, No. 4 465-469
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

POSTOPERATIVE ANALGESIA WITH EXTRADURAL CLONIDINE

FRANCIS BONNET, M.D., OLGA BOICO, M.D., SYLVIE ROSTAING, M.D., MICHEL SAADA, M.D., JEAN-FRANCOIS LORIFERNE, M.D., CHARLES TOUBOUL, M.D., KOU ABHAY, M.D. and MARCO GHIGNONE, M.D.

Department d'Anesthésie Reanimation No. 2, Hôpital Henri Mondor 51, av. du Marechal de Lattre de Tassigny, 94010, Creteil, France
Department of Anesthesiology, University of Pittsburgh Pennsylvania, U.S.A.

The analgesic effect of extradural clonidine was evaluated in a double-blind study. In the recovery room, following orthopaedic or perineal surgery 20 ASA I and II patients were allocated randomly to two groups. The extradural clonidine (EC) group received clonidine 2 µg kg–1 in isotonic saline solution 15 µg ml–1. The extradural saline (ES) group received the equivalent volume of plain isotonic saline solution. Pain was evaluated by a visual analogue scale (VAS) at 15-min intervals for the first 2 h and subsequently at 30-min intervals for the following 4 h. Morphine 5 mg was given s.c. when patients complained of pain after extradural saline or clonidine. In the EC group, the mean (SD) maximum pain relief was 68.2 (24.1)% of the initial VAS score, but it was only 14.7 (25.2)% in the ES group. The mean duration of analgesia, before injection of morphine, was significantly longer in the EC group (210 (87) min) compared with the ES group (45 (27) min) (P < 0.001). Drowsiness and moderate hypotension were observed in the EC group.


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