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British Journal of Anaesthesia, 1989, Vol. 63, No. 4 411-417
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF PROPOFOL ON THE AUDITORY EVOKED RESPONSE AND OESOPHAGEAL CONTRACTILITY

C. THORNTON, M.SC., K. M. KONIECZKO, F.F.A.R.C.S, A. B. KNIGHT, F.F.A.R.C.S.*, B. KAUL, M.D., M.B., B.S.;{dagger}, J. G. JONES, M.D., F.F.A.R.C.S., F.R.C.P.{ddagger}, C. J. DORE, B.SC. and D. C. WHITE, M.B., B.S., D.A., F.F.A.R.C.S.

Clinical Research Centre and Northwick Park Hospital Watford Road, Harrow, Middlesex HA1 3UJ

* Anaesthetic Department, Hillingdon Hospital, Uxbridge, Middx UB8 3QW.

{dagger}Department of Anaesthetics, Central Middlesex Hospital, Acton Lane, London NW10 7NS.

{ddagger}Department of Anaesthesia, University of Leeds, 24 Hype Terrace, Leeds LS2 9LN.

Correspondence to C.T.

Six patients were anaesthetized with 70% nitrous oxide in oxygen supplemented by infusion of propofol 40, 80, 120, 160 and 200 µg kg–1 min–1 sequentially in successive 10-min periods. Auditory evoked response (AER) and lower oeso-phageal contractility (LOC) were monitored. The AER findings were consistent with those noted in previous studies of i.v. agents. Early cortical waves showed attentuation of Pa and Nb amplitude (P < 0.01) and increase in Pa and Nb latency (P < 0.01; P < 0.05) with increasing blood concentrations of propofol. Brainstem waves were not affected significantly. LOC, provoked and spontaneous, showed no consistent relationship with blood concentration of propofol. The two variables AER and LOC were not related.


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