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British Journal of Anaesthesia, 1989, Vol. 62, No. 2 194-198
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

HAEMODYNAMIC EFFECTS OF VECURONIUM

J. M. K. H. WIERDA, M.D., E. MAESTRONE, M.D., A. F. BENCINI, M.D., PH.D., A. BOYER, M.D., O. M. RASHKOVSKY, M.D., H. LIP, M.D., PH.D., R. KARLICZEK, M.D., J. M. KET and S. AGOSTON, M.D., PH.D.

Research Group of the Institutes for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen Oostersingel 59, 9713 EZ Groningen, The Netherlands
Ospedale Civile, 23100 Sondrio, Italy
Sophiaziekenhuis, 8025 AB Zwolle, The Netherlands

Three hundred and twenty adults (ASA grade I, both sexes,) received diazepam 10 mg by mouth (50% received atropine 7µg kg–1 in addition) i.m. 45 min before operation. Patients were then allocated randomly to undergo general anaesthesia with either a nitrous oxide-neurolept technique or nitrous oxide-halothane. Vecuronium was administered to 50% of the patients in each anaesthetic group and heart rate and arterial pressure were monitored. Vecuronium did not influence heart rate, or systolic or diastolic arterial pressures.


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