Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by FLETCHER, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FLETCHER, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1989, Vol. 62, No. 2 168-176
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

RELATIONSHIP BETWEEN ALVEOLAR DEADSPACE AND ARTERIAL OXYGENATION IN CHILDREN WITH CONGENITAL CARDIAC DISEASE{dagger}

R. FLETCHER, M.D., F.F.A.R.C.S.

Department of Anaesthesia, University Hospital S-221 85 Lund, Sweden

Fifty-eight children were studied during nitrous oxide in oxygen and fentanyl anaesthesia before undergoing closed or open cardiac surgery. FlO2 was 0.5. Alveolar deadspace was measured using the carbon dioxide single breath test (SBT-CO2) obtained from a computerized online system for monitoring expired CO2 and airway flow, based on the Servo ventilator, Arterial blood was sampled simultaneously for measurement of PaCo2 and PaO2. There was a marked reciprocal relationship between PaO2 and the alveolar deadspace fraction. In children with a normal pulmonary circulation and good oxy-genation, alveolar deadspace fraction was approx. 0.05. Shunts which reduced PaO2 to 10 kPa produced a deadspace fraction of 0.15. When PaO2 was 3–4 kPa, alveolar deadspace fraction was approx. 0.4. In well-oxygenated children, alveolar deadspace fraction was only slightly greater than predicted by a model of the effects of pure right-to-left shunting. In severely cyanotic children, the discrepancy between predicted and observed VDa/v/VTa/v was greater. The mean arterial-end-tidal CO2 difference was zero in children in whom PaO2 was greater than 10 kPa, despite a measurable alveolar deadspace. In severely hypoxic children, the difference was 1–2 kPa. In a retrospective analysis of published data from anaesthetized adults without intracardiac shunting, no relationship was found between alveolar deadspace and PaO2.

{dagger}Previously presented in abstract form (Br. J. Anaesth. (1987), 59, 928P).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
R. A. McCahon, M. O. Columb, R. P. Mahajan, and J. G. Hardman
Validation and application of a high-fidelity, computational model of acute respiratory distress syndrome to the examination of the indices of oxygenation at constant lung-state
Br. J. Anaesth., September 1, 2008; 101(3): 358 - 365.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. B. Drummond and R. Fletcher
Editorial II: Deadspace: invasive or not?
Br. J. Anaesth., January 1, 2006; 96(1): 4 - 7.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
Y. Tang, M. J. Turner, and A. B. Baker
Effects of alveolar dead-space, shunt and V/Q distribution on respiratory dead-space measurements
Br. J. Anaesth., October 1, 2005; 95(4): 538 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. G. Hardman and A. R. Aitkenhead
Estimating Alveolar Dead Space from the Arterial to End-Tidal CO2 Gradient: A Modeling Analysis
Anesth. Analg., December 1, 2003; 97(6): 1846 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Coss-Bu, D. L. Walding, Y. B. David, and L. S. Jefferson
Dead Space Ventilation in Critically Ill Children With Lung Injury
Chest, June 1, 2003; 123(6): 2050 - 2056.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.