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British Journal of Anaesthesia, 1989, Vol. 62, No. 1 95-97
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

USE OF CONTINUOUS PROLONGED ADMINISTRATION OF ATRACURIUM IN THE ITU TO A PATIENT WITH MYASTHENIA GRAVIS

B. J. POLLARD, B. PHARM., M.B., CH.B., F.F.A.R.C.S.*, N. J. N. HARPER, M.B., CH.B., F.F.A.R.C.S. and B. R. H. DORAN, M.B., B.S., F.F.A.R.C.S.

Adult Intensive Care Unit, Manchester Royal Infirmary Oxford Road, Manchester M13 9WL

* Address for correspondence: University Department of Anaesthesia, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL.

The case is described of a patient with myasthenia gravis who required prolonged controlled ventilation for respiratory failure. Muscular relaxation was obtained with a continuous infusion of atracurium 5 mg h–1 for 45 h. Following cessation of the infusion, paralysis disappeared rapidly.


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