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British Journal of Anaesthesia, 1989, Vol. 62, No. 1 87-91
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DOES PRETREATMENT WITH CIMETIDINE AND RANITIDINE AFFECT THE DISPOSITION OF BUPIVACAINE ?

R. J. FLYNN, M.B., F.F.A.R.C.S., J. MOORE, M.D., PH.D., F.F.A.R.C.S., P. S. COLLIER, PH.D. and E. MCCLEAN, M.SC.

Department of Anaesthetics, The Queen's University of Belfast Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
Department of Pharmacy, The Queen's University of Belfast Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL

Thirty patients who chose extradural analgesia for elective Caesarean section were pretreated, by random selection, with cimetidine 400 mg, ranitidine 150 mg or no H2-blocker. Following the administration of 0.5% bupivacaine, no significant difference was found between peak plasma bupivacaine concentrations or area under the plasma bupivacaine concentration-time curve (AUC) in these three groups. This study shows that a single dose of cimetidine or ranitidine does not affect significantly the disposition of bupivacaine in the obstetric patient.


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