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British Journal of Anaesthesia, 1989, Vol. 62, No. 1 46-53
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPUTER CONTROLLED INFUSION OF PROPOFOL

R. M. TACKLEY, B.SC., M.B.B.S., F.F.A.R.C.S., G. T. R. LEWIS, M.SC., B.TECH, C. PRYS-ROBERTS, D.M., PH.D., F.F.A.R.C.S., F.F.A.R.A.C.S., R. W. BOADEN, M.B.B.S., F.F.A.R.C.S.*, J. DIXON, M.B.B.S., F.F.A.R.C.S.{dagger} and J. T. HARVEY

Department of Medical Physics, Bristol Royal Infirmary Bristol BS16 1LE
Sir Humphry Davy Department of Anaesthetics, Bristol Royal Infirmary Bristol BS16 1LE

A computer controlled infusion pump was used to deliver propofol to two groups of eight patients undergoing body surface surgery. The patients were premedicated with morphine sulphate i.m. and anaesthesia was supplemented with 66% nitrous oxide in oxygen. Patients in group 1 breathed spontaneously, whereas patients in group 2 underwent artificial ventilation to a normal Paco2. The computer program was designed to achieve and maintain a blood concentration of propofol 3 µg ml–1 as rapidly as possible, basing calculations on a three-compartment pharmacokinetic model. Mean blood propofol concentrations were found to be close to the predicted target from 10 to 120 min in group 1, but were 5–20% higher from 20 min in group 2.

*Department of Anaesthetics, Royal Devon and Exeter Hospital (Wonford), Barrack Road, Exeter, Devon.

{dagger}Department of Anaesthetics, Weston General Hospital, Weston General Hospital, Weston Super Mare, Devon.


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