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British Journal of Anaesthesia, 1989, Vol. 62, No. 1 33-40
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF HALOTHANE, ENFLURANE AND ISOFLURANE ON CAROTID BODY CHEMORECEPTOR ACTIVITY IN THE RABBIT AND THE CAT

J. PONTE, M.D., D.I.C., PH.D, F.F.A.R.C.S. and C. L. SADLER, B.SC., PH.D.

Department of Anaesthesia, King's College School of Medicine and Dentistry Bessemer Road, London SE5 9PJ

The response of the carotid body chemoreceptors to administration of halothane, enflurane and isoflurane was tested in the rabbit and cat. In the steady-state all three volatile anaesthetics, in doses up to 1%, were mildly chemodepressant. The oxygen response curves were shifted down-wards, but hypoxic stimuli below 5.3 kPa over-came this chemodepression. Two-point carbon dioxide response curves were also shifted downwards, but with no change in slope. Possible mechanisms involved in the chemoreceptor response to transient and steady-state anaesthetic administration are discussed.


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