British Journal of Anaesthesia, 1989, Vol. 62, No. 1 104-107
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia
case-report |
FATAL HAEMOPATHOLOGICAL CONSEQUENCES OF GENERAL ANAESTHESIA
Department of Anaesthetics, Royal Hallamshire Hospital Glossop Road, Sheffield
Department of Pathology, Royal Hallamshire Hospital Glossop Road, Sheffield
Department of Immunology, Royal Hallamshire Hospital Glossop Road, Sheffield
A previously healthy 63-yr-old female died following an anaphylactoid response to anaesthesia with thiopentone and suxamethonium. Postmortem findings strongly suggested that disseminated intravascular coagulation played a significant role in her death. The local mechanism behind the reaction is unknown, but the formation of thiopentone-suxamethonium colloid aggregates during induction, may have lead to "aggregate anaphylaxis".