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British Journal of Anaesthesia, 1988, Vol. 61, No. 5 598-600
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CHANGES IN PUPIL DIAMETER AFTER ORAL ADMINISTRATION OF CODEINE

J. E. PEACOCK, M.B., CH.B., F.F.A.R.C.S., P. D. HENDERSON and W. S. NIMMO, B.SC., M.D., F.R.C.P., F.F.A.R.C.S.

University Department of Anaesthesia, University of Sheffield Medical School Beech Hill Road, Sheffield S10 2JF

Pupillary constriction occurs following administration of opioids and may be used as a marker of opioid activity. We have measured plasma concentrations and pupil diameters in 16 healthy volunteers after the oral administration of placebo or codeine. Pupil size decreased significantly after codeine compared with placebo. Pupil size was related to the plasma concentrations of codeine (P < 0.05).


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