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British Journal of Anaesthesia, 1988, Vol. 61, No. 5 583-588
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PROLONGED SEDATION WITH PROPOFOL IN ICU PATIENTS: RECOVERY AND BLOOD CONCENTRATION CHANGES DURING PERIODIC INTERRUPTIONS IN INFUSION

J. P. BELLER, M.D., T. POTTECHER, M.D., A. LUGNIER, PH.D., P. MANGIN, M.D. and J. C. OTTENI, M.D.

Service d'anesthésie-réanimation chirurgicale, Hóspital de Hautepierre 67200- Strasbourg, France
Institut de Médecine Légale, Faculté de Médecine 67000 - Strasbourg, France

Correspondence to J.P.B.

Propofol (mean dose 2.85 mg kg–1 h–1) was administered for 4 days by continuous i. v. infusion for sedation in 14 agitated and restless ICU patients. This provided rapid control of the level of sedation. When the infusion was discontinued, adequate recovery with response to commands was obtained in most patients by 10 min. Recovery times and the decrease in blood propofol concentration were similar after 24, 48, 72 and 96 h of infusion. Cumulative effects, tachyphylaxis, or other untoward effects were not observed.


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