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British Journal of Anaesthesia, 1988, Vol. 61, No. 5 557-559
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF ATRACURIUM AND VECURONIUM DURING ANAESTHESIA FOR LAPAROSCOPY

D. M. BAILEY, M.B., B.S., F.F.A.R.C.S. and A. D. G. NICHOLAS, M.B., B.S., F.F.A.R.C.S.

Department of Anaesthesia, Royal Hallamshire Hospital Glossop Road, Sheffield S10 2RX
Jessop Hospital for Women Leavygreave Road, Sheffield S10

Atracurium 0.3 mg kg–1 and vecuronium 0.06 mg kg–1 were compared directly in a double-blind randomized trial during anaesthesia for laparoscopy in 57 healthy young women. The effects of the drugs were monitored using a portable electromyograph. Both drugs provided adequate intubating conditions at 3 min, and prompt antagonism of paralysis after administration of neostigmine, but recovery was significantly faster with vecuronium (mean time to 20% recovery of control electromyographic response: vecuronium 15.1 min; atracurium 20.6 min (P < 0.001)). Atracurium caused a higher frequency of clinically observed allergoid reactions (21%) compared with vecuronium (3%).


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