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British Journal of Anaesthesia, 1988, Vol. 61, No. 3 347-349
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

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EFFECTS OF ISOFLURANE ON INTRAVENTRICULAR PRESSURE IN NEUROSURGICAL PATIENTS

J. J. GOMEZ SAINZ, M.D., J. A. ELEXPURU CAMIRUAGA, M.D., F. FERNANDEZ CANO, M.D. and J. L. DE LA HERRAN, M.D.

Servicio de Anestesia y Reanimación Santo Hospital Civil, Avendia de Montevideo n 18, 48013-Bilbao, Spain
Servicio de Neurocirugia) Santo Hospital Civil, Avenida de Montevideo n 18, 48013-Bilbao, Spain

Correspondence to J.J.G.S.

The effect of isoflurane on intraventricular pressure (IVP) was examined during nitrous oxide with fentanyl anaesthesia in patients undergoing craniotomy during normocapnia or hypocapnia. Hypocapnic patients (n = 30, PaCo2 3.3 (0.1) kPa) were allocated to three groups (A, B, C; n = 10 each) according to the inspired concentration of isoflurane (1%, 1.5%, 2%). Normocapnic patients (n = 10, PaCO2 4.7 (0.1) kPa) received an inspired concentration of 1% isoflurane (group D). In patients in groups C and D, IVP increased significantly in response to isoflurane (P < 0.01). In groups A and B, IVP did not change significantly (P > 0.05). Mean arterial pressure and cerebral perfusion pressure decreased significantly (P < 0.001) in all groups in response to isoflurane.


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