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British Journal of Anaesthesia, 1988, Vol. 61, No. 3 297-301
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS OF DROPERIDOL IN SURGICAL PATIENTS UNDER DIFFERENT CONDITIONS OF ANAESTHESIA

K. A. LEHMANN, PH.D., M.D., A. VAN PEER, PH.D., M. IKONOMAKIS, M.D., R. GASPARINI, CHEM.ENG. and J. HEYKANTS, PH.D.

Department of Anaesthesiology, University of Köln, Joseph-Stelzmann-Strasse 9, D-5000 Köln 41, Germany
Department of Drug Metabolism and Pharmacokinetics Janssen Pharmaceutica, Turnhoutseweg 30, B-2340 Beerse, Belgium

The pharmacokinetics of droperidol were studied in 42 surgical patients using doses of 5, 10 and 15 mg i.v., in association with neuro-leptanalgesia or volatile anaesthetics. Plasma concentrations of droperidol were measured by radioimmunoassay. During neuroleptanalgesia, droperidol kinetics were linear over the dose range tested: the overall mean elimination half-life was 127 min, Vdss 103 litre and the plasma clearance 732 ml min–1. The kinetics of droperidol were similar under neuroleptanalgesia and under anaesthesia with halothane or enflurane. There was no significant correlation between the volume of distribution or clearance with age (14–65 yr) or body weight (48–90 kg).


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